Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo

Inactivation of phosphatase and tensin homology deleted on chromosome 10 (PTEN) is linked to increased PI3K–AKT signaling, enhanced organismal growth, and cancer development. Here we generated and analyzed Pten knock-in mice harboring a C2 domain missense mutation at phenylalanine 341 (Pten(FV)), fo...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genes Dev
Prif Awduron: Caserta, Enrico, Egriboz, Onur, Wang, Hui, Martin, Chelsea, Koivisto, Christopher, Pecót, Thierry, Kladney, Raleigh D., Shen, Changxian, Shim, Kang-Sup, Pham, Thac, Karikomi, Matthew K., Mauntel, Melissa J., Majumder, Sarmila, Cuitino, Maria C., Tang, Xing, Srivastava, Arunima, Yu, Lianbo, Wallace, Julie, Mo, Xiaokui, Park, Morag, Fernandez, Soledad A., Pilarski, Robert, La Perle, Krista M.D., Rosol, Thomas J., Coppola, Vincenzo, Castrillon, Diego H., Timmers, Cynthia, Cohn, David E., O'Malley, David M., Backes, Floor, Suarez, Adrian A., Goodfellow, Paul, Chamberlin, Helen M., Macrae, Erin R., Shapiro, Charles L., Ostrowski, Michael C., Leone, Gustavo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2015
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561480/
https://ncbi.nlm.nih.gov/pubmed/26302789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.262568.115
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