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Allele-specific tumor spectrum in Pten knockin mice

Germline mutations in the tumor suppressor gene PTEN (phosphatase and tensin homology deleted on chromosome 10) cause Cowden and Bannayan–Riley–Ruvalcaba (BRR) syndromes, two dominantly inherited disorders characterized by mental retardation, multiple hamartomas, and variable cancer risk. Here, we m...

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Bibliografiske detaljer
Main Authors: Wang, Hui, Karikomi, Matt, Naidu, Shan, Rajmohan, Ravi, Caserta, Enrico, Chen, Hui-Zi, Rawahneh, Maysoon, Moffitt, Julie, Stephens, Julie A., Fernandez, Soledad A., Weinstein, Michael, Wang, Danxin, Sadee, Wolfgang, La Perle, Krista, Stromberg, Paul, Rosol, Thomas J., Eng, Charis, Ostrowski, Michael C., Leone, Gustavo
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841921/
https://ncbi.nlm.nih.gov/pubmed/20194734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912524107
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