Discovery of stromal regulatory networks that suppress Ras-sensitized epithelial cell proliferation

Mesodermal cells signal to neighboring epithelial cells to modulate their proliferation in both normal and disease states. We adapted a C. elegans organogenesis model to enable a genome-wide mesodermal-specific RNAi screen and discovered 39 factors in mesodermal cells that suppress the proliferation...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Liu, Huayang, Dowdle, James A., Khurshid, Safiya, Sullivan, Nicholas J., Bertos, Nicholas, Rambani, Komal, Mair, Markus, Daniel, Piotr, Wheeler, Esther, Tang, Xing, Toth, Kyle, Lause, Michael, Harrigan, Markus E., Eiring, Karl, Sullivan, Connor, Sullivan, Matthew J., Chang, Serena W., Srivastava, Siddhant, Conway, Joseph S., Kladney, Raleigh, McElroy, Joseph, Bae, Sooin, Lu, Yuanzhi, Tofigh, Ali, Saleh, Sadiq M. I., Fernandez, Soledad A., Parvin, Jeffrey D., Coppola, Vincenzo, Macrae, Erin R., Majumder, Sarmila, Shapiro, Charles L., Yee, Lisa D., Ramaswamy, Bhuvaneswari, Hallett, Michael, Ostrowski, Michael C., Park, Morag, Chamberlin, Helen M., Leone, Gustavo
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508591/
https://ncbi.nlm.nih.gov/pubmed/28535374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.04.024
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