Anti-microRNA-222 (Anti-miR-222) and -181B Suppress Growth of Tamoxifen-resistant Xenografts in Mouse by Targeting TIMP3 Protein and Modulating Mitogenic Signal

We have shown earlier that miR-221 and -222 are up-regulated in tamoxifen-resistant MCF-7 (OHT(R)) cells and Her2-positive human breast tumors when compared with Her2 negative tumors. In this study, we report markedly enhanced expression of miR-181b in OHT(R) cells and endocrine-resistant tumors. Fu...

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Bibliografiske detaljer
Main Authors: Lu, Yuanzhi, Roy, Satavisha, Nuovo, Gerard, Ramaswamy, Bhuvaneswari, Miller, Tyler, Shapiro, Charles, Jacob, Samson T., Majumder, Sarmila
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234972/
https://ncbi.nlm.nih.gov/pubmed/22009755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.270926
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