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Hedgehog Signaling Is a Novel Therapeutic Target in Tamoxifen-Resistant Breast Cancer Aberrantly Activated by PI3K/AKT Pathway

Endocrine resistance is a major challenge in the management of estrogen receptor (ER)-positive breast cancers. Although multiple mechanisms leading to endocrine resistance have been proposed, the poor outcome of patients developing resistance to endocrine therapy warrants additional studies. Here we...

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Hlavní autoři: Ramaswamy, Bhuvaneswari, Lu, Yuanzhi, Teng, Kun-yu, Nuovo, Gerard, Li, Xiaobai, Shapiro, Charles L., Majumder, Sarmila
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837449/
https://ncbi.nlm.nih.gov/pubmed/22875023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1248
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