TGFβ mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3

To identify microRNAs that may play a causal role in hepatocarcinogenesis, we used an animal model in which C57/BL6 mice fed choline deficient and amino acid defined (CDAA) diet develop preneoplastic lesions at 65 weeks and hepatocellular carcinomas after 84 weeks. miRNA expression profiling showed...

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Detalhes bibliográficos
Main Authors: Wang, Bo, Hsu, Shu-Hao, Majumder, Sarmila, Kutay, Huban, Huang, Wei, Jacob, Samson T., Ghoshal, Kalpana
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845743/
https://ncbi.nlm.nih.gov/pubmed/20023698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.468
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