Estrogen-Mediated Suppression of the Gene Encoding Protein Tyrosine Phosphatase PTPRO in Human Breast Cancer: Mechanism and Role in Tamoxifen Sensitivity

We have previously demonstrated the tumor suppressor characteristics of protein tyrosine phosphatase receptor-type O (PTPRO) in leukemia and lung cancer, including its suppression by promoter methylation. Here, we show tumor-specific methylation of the PTPRO CpG island in primary human breast cancer...

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Detalhes bibliográficos
Main Authors: Ramaswamy, Bhuvaneswari, Majumder, Sarmila, Roy, Satavisha, Ghoshal, Kalpana, Kutay, Huban, Datta, Jharna, Younes, Mamoun, Shapiro, Charles L., Motiwala, Tasneem, Jacob, Samson T.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646619/
https://ncbi.nlm.nih.gov/pubmed/19095770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0211
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