5-Aza-Deoxycytidine Induces Selective Degradation of DNA Methyltransferase 1 by a Proteasomal Pathway That Requires the KEN Box, Bromo-Adjacent Homology Domain, and Nuclear Localization Signal

5-Azacytidine- and 5-aza-deoxycytidine (5-aza-CdR)-mediated reactivation of tumor suppressor genes silenced by promoter methylation has provided an alternate approach in cancer therapy. Despite the importance of epigenetic therapy, the mechanism of action of DNA-hypomethylating agents in vivo has no...

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Detalhes bibliográficos
Main Authors: Ghoshal, Kalpana, Datta, Jharna, Majumder, Sarmila, Bai, Shoumei, Kutay, Huban, Motiwala, Tasneem, Jacob, Samson T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140649/
https://ncbi.nlm.nih.gov/pubmed/15899874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.11.4727-4741.2005
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