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HOXB13, a Target of DNMT3B, Is Methylated at an Upstream CpG Island, and Functions as a Tumor Suppressor in Primary Colorectal Tumors

BACKGROUND: A hallmark of cancer cells is hypermethylation of CpG islands (CGIs), which probably arises from upregulation of one or more DNA methyltransferases. The purpose of this study was to identify the targets of DNMT3B, an essential DNA methyltransferase in mammals, in colon cancer. METHODOLOG...

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主要な著者: Ghoshal, Kalpana, Motiwala, Tasneem, Claus, Rainer, Yan, Pearlly, Kutay, Huban, Datta, Jharna, Majumder, Sarmila, Bai, Shoumei, Majumder, Arnab, Huang, Tim, Plass, Christoph, Jacob, Samson T.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2010
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861599/
https://ncbi.nlm.nih.gov/pubmed/20454457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010338
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