HOXB13, a Target of DNMT3B, Is Methylated at an Upstream CpG Island, and Functions as a Tumor Suppressor in Primary Colorectal Tumors

BACKGROUND: A hallmark of cancer cells is hypermethylation of CpG islands (CGIs), which probably arises from upregulation of one or more DNA methyltransferases. The purpose of this study was to identify the targets of DNMT3B, an essential DNA methyltransferase in mammals, in colon cancer. METHODOLOG...

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Detalhes bibliográficos
Main Authors: Ghoshal, Kalpana, Motiwala, Tasneem, Claus, Rainer, Yan, Pearlly, Kutay, Huban, Datta, Jharna, Majumder, Sarmila, Bai, Shoumei, Majumder, Arnab, Huang, Tim, Plass, Christoph, Jacob, Samson T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861599/
https://ncbi.nlm.nih.gov/pubmed/20454457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010338
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