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Role of Human Ribosomal RNA (rRNA) Promoter Methylation and of Methyl-CpG-binding Protein MBD2 in the Suppression of rRNA Gene Expression

The methylation status of the CpG island located within the ribosomal RNA (rRNA) promoter in human hepatocellular carcinomas and pair-matched liver tissues was analyzed by bisulfite genomic sequencing. Significant hypomethylation of methyl-CpGs in the rRNA promoter was observed in the tumor samples...

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Bibliografiske detaljer
Main Authors: Ghoshal, Kalpana, Majumder, Sarmila, Datta, Jharna, Motiwala, Tasneem, Bai, Shoumei, Sharma, Sudarshana M., Frankel, Wendy, Jacob, Samson T.
Format: Artigo
Sprog:Inglês
Udgivet: 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242730/
https://ncbi.nlm.nih.gov/pubmed/14610093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M309393200
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