Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors

di Hart, Amy C., Schroeder, Gretchen M., Wan, Honghe, Grebinski, James, Inghrim, Jennifer, Kempson, James, Guo, Junqing, Pitts, William J., Tokarski, John S., Sack, John S., Khan, Javed A., Lippy, Jonathan, Lorenzi, Matthew V., You, Dan, McDevitt, Theresa, Vuppugalla, Ragini, Zhang, Yueping, Lombardo, Louis J., Trainor, George L., Purandare, Ashok V.
Pubblicato in ACS Med Chem Lett (2015)

Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis

di Spergel, Steven H., Mertzman, Michael E., Kempson, James, Guo, Junqing, Stachura, Sylwia, Haque, Lauren, Lippy, Jonathan S., Zhang, Rosemary F., Galella, Michael, Pitt, Sidney, Shen, Guoxiang, Fura, Aberra, Gillooly, Kathleen, McIntyre, Kim W., Tang, Vicky, Tokarski, John, Sack, John S., Khan, Javed, Carter, Percy H., Barrish, Joel C., Nadler, Steven G., Salter-Cid, Luisa M., Schieven, Gary L., Wrobleski, Stephen T., Pitts, William J.
Pubblicato in ACS Med Chem Lett (2019)

Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK

di Srivastava, Anurag S., Ko, Soo, Watterson, Scott H., Pattoli, Mark A., Skala, Stacey, Cheng, Lihong, Obermeier, Mary T., Vickery, Rodney, Discenza, Lorell N., D’Arienzo, Celia J., Gillooly, Kathleen M., Taylor, Tracy L., Pulicicchio, Claudine, McIntyre, Kim W., Yip, Shiuhang, Li, Peng, Sun, Dawn, Wu, Dauh-Rurng, Dai, Jun, Wang, Chunlei, Zhang, Yingru, Wang, Bei, Pawluczyk, Joseph, Kempson, James, Zhao, Rulin, Hou, Xiaoping, Rampulla, Richard, Mathur, Arvind, Galella, Michael A., Salter-Cid, Luisa, Barrish, Joel C., Carter, Percy H., Fura, Aberra, Burke, James R., Tino, Joseph A.
Pubblicato in ACS Med Chem Lett (2020)

Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors

di Cherney, Emily C., Zhang, Liping, Guo, Weiwei, Huang, Audris, Williams, David, Seitz, Steven, Shan, Weifang, Zhu, Xiao, Gullo-Brown, Johnni, Maley, Derrick, Lin, Tai-an, Hunt, John T., Huang, Christine, Yang, Zheng, D’Arienzo, Celia J., Discenza, Lorell N., Ranasinghe, Asoka, Grubb, Mary F., Traeger, Sarah C., Li, Xin, Johnston, Kathy A., Kopcho, Lisa, Fereshteh, Mark, Foster, Kimberly A., Stefanski, Kevin, Delpy, Diane, Dhar, Gopal, Anandam, Aravind, Mahankali, Sandeep, Padmanabhan, Shweta, Rajanna, Prabhakar, Murali, Venkata, Mariappan, T. Thanga, Pattasseri, Shabeerali, Nimje, Roshan Y., Hong, Zhenqiu, Kempson, James, Rampulla, Richard, Mathur, Arvind, Gupta, Anuradha, Borzilleri, Robert, Vite, Gregory, Balog, Aaron
Pubblicato in ACS Med Chem Lett (2021)

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder

di Marcin, Lawrence R., Warrier, Jayakumar, Thangathirupathy, Srinivasan, Shi, Jianliang, Karageorge, George N., Pearce, Bradley C., Ng, Alicia, Park, Hyunsoo, Kempson, James, Li, Jianqing, Zhang, Huiping, Mathur, Arvind, Reddy, Aliphedi B., Nagaraju, G., Tonukunuru, Gopikishan, Gupta, Grandhi V. R. K. M., Kamble, Manjunatha, Mannoori, Raju, Cheruku, Srinivas, Jogi, Srinivas, Gulia, Jyoti, Bastia, Tanmaya, Sanmathi, Charulatha, Aher, Jayant, Kallem, Rajareddy, Srikumar, Bettadapura N., Vijaya, Kumar Kuchibhotla, Naidu, Pattipati S., Paschapur, Mahesh, Kalidindi, Narasimharaju, Vikramadithyan, Reeba, Ramarao, Manjunath, Denton, Rex, Molski, Thaddeus, Shields, Eric, Subramanian, Murali, Zhuo, Xiaoliang, Nophsker, Michelle, Simmermacher, Jean, Sinz, Michael, Albright, Charlie, Bristow, Linda J., Islam, Imadul, Bronson, Joanne J., Olson, Richard E., King, Dalton, Thompson, Lorin A., Macor, John E.
Pubblicato in ACS Med Chem Lett (2018)