The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

Por Soares, Holly D., Gasior, Maciej, Toyn, Jeremy H., Wang, Jun-Sheng, Hong, Quan, Berisha, Flora, Furlong, Michael T., Raybon, Joseph, Lentz, Kimberley A., Sweeney, Francis, Zheng, Naiyu, Akinsanya, Billy, Berman, Robert M., Thompson, Lorin A., Olson, Richard E., Morrison, John, Drexler, Dieter M., Macor, John E., Albright, Charlie F., Ahlijanian, Michael K., AbuTarif, Malaz
Publicado no J Pharmacol Exp Ther (2016)

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

Por Gillman, Kevin W., Starrett, John E., Parker, Michael F., Xie, Kai, Bronson, Joanne J., Marcin, Lawrence R., McElhone, Kate E., Bergstrom, Carl P., Mate, Robert A., Williams, Richard, Meredith, Jere E., Burton, Catherine R., Barten, Donna M., Toyn, Jeremy H., Roberts, Susan B., Lentz, Kimberley A., Houston, John G., Zaczek, Robert, Albright, Charles F., Decicco, Carl P., Macor, John E., Olson, Richard E.
Publicado em 2010

BMS-933043, a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia

Por King, Dalton, Iwuagwu, Christiana, Cook, Jim, McDonald, Ivar M., Mate, Robert, Zusi, F. Christopher, Hill, Matthew D., Fang, Haiquan, Zhao, Rulin, Wang, Bei, Easton, Amy E., Miller, Regina, Post-Munson, Debra, Knox, Ronald J., Gallagher, Lizbeth, Westphal, Ryan, Molski, Thaddeus, Fan, Jingsong, Clarke, Wendy, Benitex, Yulia, Lentz, Kimberley A., Denton, Rex, Morgan, Daniel, Zaczek, Robert, Lodge, Nicholas J., Bristow, Linda J., Macor, John E., Olson, Richard E.
Publicado no ACS Med Chem Lett (2017)

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects

Por Toyn, Jeremy H., Boy, Kenneth M., Raybon, Joseph, Meredith, Jere E., Robertson, Alan S., Guss, Valerie, Hoque, Nina, Sweeney, Francis, Zhuo, Xiaoliang, Clarke, Wendy, Snow, Kimberly, Denton, R. Rex, Zuev, Dmitry, Thompson, Lorin A., Morrison, John, Grace, James, Berisha, Flora, Furlong, Michael, Wang, Jun-Sheng, Lentz, Kimberly A., Padmanabha, Ramesh, Cook, Lynda, Wei, Cong, Drexler, Dieter M., Macor, John E., Albright, Charlie F., Gasior, Maciej, Olson, Richard E., Hong, Quan, Soares, Holly D., AbuTarif, Malaz, Ahlijanian, Michael K.
Publicado no J Pharmacol Exp Ther (2016)

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780

Por Toyn, Jeremy H., Thompson, Lorin A., Lentz, Kimberley A., Meredith, Jere E., Burton, Catherine R., Sankaranararyanan, Sethu, Guss, Valerie, Hall, Tracey, Iben, Lawrence G., Krause, Carol M., Krause, Rudy, Lin, Xu-Alan, Pierdomenico, Maria, Polson, Craig, Robertson, Alan S., Denton, R. Rex, Grace, James E., Morrison, John, Raybon, Joseph, Zhuo, Xiaoliang, Snow, Kimberly, Padmanabha, Ramesh, Agler, Michele, Esposito, Kim, Harden, David, Prack, Margaret, Varma, Sam, Wong, Victoria, Zhu, Yingjie, Zvyaga, Tatyana, Gerritz, Samuel, Marcin, Lawrence R., Higgins, Mendi A., Shi, Jianliang, Wei, Cong, Cantone, Joseph L., Drexler, Dieter M., Macor, John E., Olson, Richard E., Ahlijanian, Michael K., Albright, Charles F.
Publicado em 2014