Interpreting Alzheimer’s disease clinical trials in light of the effects on amyloid-β

gan Toyn, Jeremy H, Ahlijanian, Michael K
Cyhoeddwyd 2014

A randomized, single ascending dose study of intravenous BIIB092 in healthy participants

gan Qureshi, Irfan A., Tirucherai, Giridhar, Ahlijanian, Michael K., Kolaitis, Gerry, Bechtold, Clifford, Grundman, Michael
Cyhoeddwyd yn Alzheimers Dement (N Y) (2018)

NR2B Antagonist CP-101,606 Abolishes Pitch-Mediated Deviance Detection in Awake Rats

gan Sivarao, Digavalli V., Chen, Ping, Yang, Yili, Li, Yu-Wen, Pieschl, Rick, Ahlijanian, Michael K.
Cyhoeddwyd 2014

Development of a spontaneously active dorsal root ganglia assay using multiwell multielectrode arrays

gan Newberry, Kim, Wang, Shuya, Hoque, Nina, Kiss, Laszlo, Ahlijanian, Michael K., Herrington, James, Graef, John D.
Cyhoeddwyd yn J Neurophysiol (2016)

Partial Rescue of the p35−/− Brain Phenotype by Low Expression of a Neuronal-Specific Enolase p25 Transgene

gan Patzke, Holger, Maddineni, Upendra, Ayala, Ramses, Morabito, Maria, Volker, Janet, Dikkes, Pieter, Ahlijanian, Michael K., Tsai, Li-Huei
Cyhoeddwyd yn J Neurosci (2003)

40 Hz Auditory Steady-State Response Is a Pharmacodynamic Biomarker for Cortical NMDA Receptors

gan Sivarao, Digavalli V, Chen, Ping, Senapati, Arun, Yang, Yili, Fernandes, Alda, Benitex, Yulia, Whiterock, Valerie, Li, Yu-Wen, Ahlijanian, Michael K
Cyhoeddwyd yn Neuropsychopharmacology (2016)

APP processing is regulated by cytoplasmic phosphorylation

gan Lee, Ming-Sum, Kao, Shih-Chu, Lemere, Cynthia A., Xia, Weiming, Tseng, Huang-Chun, Zhou, Ying, Neve, Rachael, Ahlijanian, Michael K., Tsai, Li-Huei
Cyhoeddwyd 2003

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

gan Ahlijanian, Michael K., Barrezueta, Nestor X., Williams, Robert D., Jakowski, Amy, Kowsz, Kim P., McCarthy, Sheryl, Coskran, Timothy, Carlo, Anthony, Seymour, Patricia A., Burkhardt, John E., Nelson, Robert B., McNeish, John D.
Cyhoeddwyd 2000

Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents

gan Wu, Yong-Jin, Guernon, Jason, Yang, Fukang, Snyder, Lawrence, Shi, Jianliang, Mcclure, Andrea, Rajamani, Ramkumar, Park, Hyunsoo, Ng, Alicia, Lewis, Hal, Chang, ChiehYing, Camac, Dan, Toyn, Jeremy H., Ahlijanian, Michael K., Albright, Charles F., Macor, John E., Thompson, Lorin A.
Cyhoeddwyd yn ACS Med Chem Lett (2016)

The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

gan Soares, Holly D., Gasior, Maciej, Toyn, Jeremy H., Wang, Jun-Sheng, Hong, Quan, Berisha, Flora, Furlong, Michael T., Raybon, Joseph, Lentz, Kimberley A., Sweeney, Francis, Zheng, Naiyu, Akinsanya, Billy, Berman, Robert M., Thompson, Lorin A., Olson, Richard E., Morrison, John, Drexler, Dieter M., Macor, John E., Albright, Charlie F., Ahlijanian, Michael K., AbuTarif, Malaz
Cyhoeddwyd yn J Pharmacol Exp Ther (2016)

USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

gan Rusilowicz-Jones, Emma V, Jardine, Jane, Kallinos, Andreas, Pinto-Fernandez, Adan, Guenther, Franziska, Giurrandino, Mariacarmela, Barone, Francesco G, McCarron, Katy, Burke, Christopher J, Murad, Alejandro, Martinez, Aitor, Marcassa, Elena, Gersch, Malte, Buckmelter, Alexandre J, Kayser-Bricker, Katherine J, Lamoliatte, Frederic, Gajbhiye, Akshada, Davis, Simon, Scott, Hannah C, Murphy, Emma, England, Katherine, Mortiboys, Heather, Komander, David, Trost, Matthias, Kessler, Benedikt M, Ioannidis, Stephanos, Ahlijanian, Michael K, Urbé, Sylvie, Clague, Michael J
Cyhoeddwyd yn Life Sci Alliance (2020)

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481

gan Boy, Kenneth M., Guernon, Jason M., Zuev, Dmitry S., Xu, Li, Zhang, Yunhui, Shi, Jianliang, Marcin, Lawrence R., Higgins, Mendi A., Wu, Yong-Jin, Krishnananthan, Subramaniam, Li, Jianqing, Trehan, Ashok, Smith, Daniel, Toyn, Jeremy H., Meredith, Jere E., Burton, Catherine R., Kimura, S. Roy, Zvyaga, Tatyana, Zhuo, Xiaoliang, Lentz, Kimberley A., Grace, James E., Denton, Rex, Morrison, John S., Mathur, Arvind, Albright, Charles F., Ahlijanian, Michael K., Olson, Richard E., Thompson, Lorin A., Macor, John E.
Cyhoeddwyd yn ACS Med Chem Lett (2019)

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects

gan Toyn, Jeremy H., Boy, Kenneth M., Raybon, Joseph, Meredith, Jere E., Robertson, Alan S., Guss, Valerie, Hoque, Nina, Sweeney, Francis, Zhuo, Xiaoliang, Clarke, Wendy, Snow, Kimberly, Denton, R. Rex, Zuev, Dmitry, Thompson, Lorin A., Morrison, John, Grace, James, Berisha, Flora, Furlong, Michael, Wang, Jun-Sheng, Lentz, Kimberly A., Padmanabha, Ramesh, Cook, Lynda, Wei, Cong, Drexler, Dieter M., Macor, John E., Albright, Charlie F., Gasior, Maciej, Olson, Richard E., Hong, Quan, Soares, Holly D., AbuTarif, Malaz, Ahlijanian, Michael K.
Cyhoeddwyd yn J Pharmacol Exp Ther (2016)

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780

gan Toyn, Jeremy H., Thompson, Lorin A., Lentz, Kimberley A., Meredith, Jere E., Burton, Catherine R., Sankaranararyanan, Sethu, Guss, Valerie, Hall, Tracey, Iben, Lawrence G., Krause, Carol M., Krause, Rudy, Lin, Xu-Alan, Pierdomenico, Maria, Polson, Craig, Robertson, Alan S., Denton, R. Rex, Grace, James E., Morrison, John, Raybon, Joseph, Zhuo, Xiaoliang, Snow, Kimberly, Padmanabha, Ramesh, Agler, Michele, Esposito, Kim, Harden, David, Prack, Margaret, Varma, Sam, Wong, Victoria, Zhu, Yingjie, Zvyaga, Tatyana, Gerritz, Samuel, Marcin, Lawrence R., Higgins, Mendi A., Shi, Jianliang, Wei, Cong, Cantone, Joseph L., Drexler, Dieter M., Macor, John E., Olson, Richard E., Ahlijanian, Michael K., Albright, Charles F.
Cyhoeddwyd 2014