Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

Hyperphosphorylation of microtubule-associated proteins such as tau and neurofilament may underlie the cytoskeletal abnormalities and neuronal death seen in several neurodegenerative diseases including Alzheimer's disease. One potential mechanism of microtubule-associated protein hyperphosphory...

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Detalhes bibliográficos
Main Authors: Ahlijanian, Michael K., Barrezueta, Nestor X., Williams, Robert D., Jakowski, Amy, Kowsz, Kim P., McCarthy, Sheryl, Coskran, Timothy, Carlo, Anthony, Seymour, Patricia A., Burkhardt, John E., Nelson, Robert B., McNeish, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC16029/
https://ncbi.nlm.nih.gov/pubmed/10706614
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