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Deregulation of cdk5, Hyperphosphorylation, and Cytoskeletal Pathology in the Niemann–Pick Type C Murine Model
NPC-1 gene mutations cause Niemann–Pick type C (NPC), a neurodegenerative storage disease resulting in premature death in humans. Spontaneous mutation of the NPC-1 gene in mice generates a similar phenotype, usually with death ensuing by 12 weeks of age. Both human and murine NPC are characterized n...
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| Publicado en: | J Neurosci |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Society for Neuroscience
2002
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6758154/ https://ncbi.nlm.nih.gov/pubmed/12151531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-15-06515.2002 |
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