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p35/p25 Is Not Essential for Tau and Cytoskeletal Pathology or Neuronal Loss in Niemann–Pick Type C Disease
Hyperactivation of the cyclin-dependent kinase 5 (cdk5), triggered by proteolytic conversion of its neuronal activator, p35, to a more potent byproduct, p25, has been implicated in Alzheimer's disease (AD), amyotrophic lateral sclerosis, and Niemann–Pick type C disease (NPC). This mechanism is...
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| Publié dans: | J Neurosci |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Society for Neuroscience
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6675168/ https://ncbi.nlm.nih.gov/pubmed/16525053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4834-05.2006 |
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