Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

Hyperphosphorylation of microtubule-associated proteins such as tau and neurofilament may underlie the cytoskeletal abnormalities and neuronal death seen in several neurodegenerative diseases including Alzheimer's disease. One potential mechanism of microtubule-associated protein hyperphosphory...

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Hlavní autoři: Ahlijanian, Michael K., Barrezueta, Nestor X., Williams, Robert D., Jakowski, Amy, Kowsz, Kim P., McCarthy, Sheryl, Coskran, Timothy, Carlo, Anthony, Seymour, Patricia A., Burkhardt, John E., Nelson, Robert B., McNeish, John D.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2000
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC16029/
https://ncbi.nlm.nih.gov/pubmed/10706614
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