Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors

[Image: see text] IDO1 inhibitors have shown promise as immunotherapies for the treatment of a variety of cancers, including metastatic melanoma and renal cell carcinoma. We recently reported the identification of several novel heme-displacing IDO1 inhibitors, including the clinical molecules linrod...

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Bibliografiset tiedot
Julkaisussa:ACS Med Chem Lett
Päätekijät: Cherney, Emily C., Zhang, Liping, Guo, Weiwei, Huang, Audris, Williams, David, Seitz, Steven, Shan, Weifang, Zhu, Xiao, Gullo-Brown, Johnni, Maley, Derrick, Lin, Tai-an, Hunt, John T., Huang, Christine, Yang, Zheng, D’Arienzo, Celia J., Discenza, Lorell N., Ranasinghe, Asoka, Grubb, Mary F., Traeger, Sarah C., Li, Xin, Johnston, Kathy A., Kopcho, Lisa, Fereshteh, Mark, Foster, Kimberly A., Stefanski, Kevin, Delpy, Diane, Dhar, Gopal, Anandam, Aravind, Mahankali, Sandeep, Padmanabhan, Shweta, Rajanna, Prabhakar, Murali, Venkata, Mariappan, T. Thanga, Pattasseri, Shabeerali, Nimje, Roshan Y., Hong, Zhenqiu, Kempson, James, Rampulla, Richard, Mathur, Arvind, Gupta, Anuradha, Borzilleri, Robert, Vite, Gregory, Balog, Aaron
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2021
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274105/
https://ncbi.nlm.nih.gov/pubmed/34267885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00236
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