Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1

[Image: see text] Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing dioxygenase enzyme implicated in cancer immune response. This account details the discovery of BMS-986242, a novel IDO1 inhibitor designed for the treatment of a variety of cancers including metastatic melanoma and renal cel...

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Publié dans:ACS Med Chem Lett
Auteurs principaux: Cherney, Emily C., Zhang, Liping, Nara, Susheel, Zhu, Xiao, Gullo-Brown, Johnni, Maley, Derrick, Lin, Tai-An, Hunt, John T., Huang, Christine, Yang, Zheng, Darienzo, Celia, Discenza, Lorell, Ranasinghe, Asoka, Grubb, Mary, Ziemba, Theresa, Traeger, Sarah C., Li, Xin, Johnston, Kathy, Kopcho, Lisa, Fereshteh, Mark, Foster, Kimberly, Stefanski, Kevin, Fargnoli, Joseph, Swanson, Jesse, Brown, Jennifer, Delpy, Diane, Seitz, Steven P., Borzilleri, Robert, Vite, Gregory, Balog, Aaron
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2021
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7883469/
https://ncbi.nlm.nih.gov/pubmed/33603977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00668
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