Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1

[Image: see text] Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing dioxygenase enzyme implicated in cancer immune response. This account details the discovery of BMS-986242, a novel IDO1 inhibitor designed for the treatment of a variety of cancers including metastatic melanoma and renal cel...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Cherney, Emily C., Zhang, Liping, Nara, Susheel, Zhu, Xiao, Gullo-Brown, Johnni, Maley, Derrick, Lin, Tai-An, Hunt, John T., Huang, Christine, Yang, Zheng, Darienzo, Celia, Discenza, Lorell, Ranasinghe, Asoka, Grubb, Mary, Ziemba, Theresa, Traeger, Sarah C., Li, Xin, Johnston, Kathy, Kopcho, Lisa, Fereshteh, Mark, Foster, Kimberly, Stefanski, Kevin, Fargnoli, Joseph, Swanson, Jesse, Brown, Jennifer, Delpy, Diane, Seitz, Steven P., Borzilleri, Robert, Vite, Gregory, Balog, Aaron
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2021
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7883469/
https://ncbi.nlm.nih.gov/pubmed/33603977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00668
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