Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors

[Image: see text] Structure–activity relationships in a series of (2-oxo-1,4-benzodiazepin-3-yl)-succinamides identified highly potent inhibitors of γ-secretase mediated signaling of Notch1/2/3/4 receptors. On the basis of its robust in vivo efficacy at tolerated doses in Notch driven leukemia and s...

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書誌詳細
出版年:ACS Med Chem Lett
主要な著者: Gavai, Ashvinikumar V., Quesnelle, Claude, Norris, Derek, Han, Wen-Ching, Gill, Patrice, Shan, Weifang, Balog, Aaron, Chen, Ke, Tebben, Andrew, Rampulla, Richard, Wu, Dauh-Rurng, Zhang, Yingru, Mathur, Arvind, White, Ronald, Rose, Anne, Wang, Haiqing, Yang, Zheng, Ranasinghe, Asoka, D’Arienzo, Celia, Guarino, Victor, Xiao, Lan, Su, Ching, Everlof, Gerry, Arora, Vinod, Shen, Ding Ren, Cvijic, Mary Ellen, Menard, Krista, Wen, Mei-Li, Meredith, Jere, Trainor, George, Lombardo, Louis J., Olson, Richard, Baran, Phil S., Hunt, John T., Vite, Gregory D., Fischer, Bruce S., Westhouse, Richard A., Lee, Francis Y.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2015
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434460/
https://ncbi.nlm.nih.gov/pubmed/26005526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00001
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