Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case

Notch pathway antagonists such as γ-secretase inhibitors (GSIs) are being tested in diverse cancers, but exceptional responses have yet to be reported. We describe the case of a patient with relapsed/refractory early T-cell progenitor acute lymphoblastic leukemia (ETP-ALL) who achieved a complete he...

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Gepubliceerd in:Cold Spring Harb Mol Case Stud
Hoofdauteurs: Knoechel, Birgit, Bhatt, Ami, Pan, Li, Pedamallu, Chandra S., Severson, Eric, Gutierrez, Alejandro, Dorfman, David M., Kuo, Frank C., Kluk, Michael, Kung, Andrew L., Zweidler-McKay, Patrick, Meyerson, Matthew, Blacklow, Stephen C., DeAngelo, Daniel J., Aster, Jon C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850884/
https://ncbi.nlm.nih.gov/pubmed/27148573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a000539
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