Mapping the binding site of BMS-708163 on γ-secretase with cleavable photoprobes

γ-Secretase, a four-subunit transmembrane aspartic proteinase, is a highly valued drug target in Alzheimer’s disease and cancer. Despite significant progress in structural studies, the respective molecular mechanisms and binding modes of γ-secretase inhibitors (GSIs) and modulators (GSMs) remain unc...

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Publicado en:Cell Chem Biol
Autores principales: Gertsik, Natalya, am Ende, Christopher W., Geoghegan, Kieran F., Nguyen, Chuong, Mukherjee, Paramita, Mente, Scot, Seneviratne, Uthpala, Johnson, Douglas S., Li, Yue-Ming
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516958/
https://ncbi.nlm.nih.gov/pubmed/28065657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.12.006
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