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Complex regulation of γ-secretase: from obligatory to modulatory subunits
γ-Secretase is a four subunit, 19-pass transmembrane enzyme that cleaves amyloid precursor protein (APP), catalyzing the formation of amyloid beta (Aβ) peptides that form amyloid plaques, which contribute to Alzheimer’s disease (AD) pathogenesis. γ-Secretase also cleaves Notch, among many other type...
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| Vydáno v: | Front Aging Neurosci |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Frontiers Media S.A.
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4285130/ https://ncbi.nlm.nih.gov/pubmed/25610395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2014.00342 |
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