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γ-Secretase inhibitors and modulators: Mechanistic insights into the function and regulation of γ-Secretase
Over two decades, γ-secretase has been the target for extensive therapeutic development due to its pivotal role in pathogenesis of Alzheimer’s disease and cancer. However, it has proven to be a challenging task owing to its large set of substrates and our limited understanding of the enzyme’s struct...
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| Publicado no: | Semin Cell Dev Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7483676/ https://ncbi.nlm.nih.gov/pubmed/32249070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2020.03.002 |
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