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Development and Mechanism of γ-Secretase Modulators for Alzheimer Disease
γ-Secretase is an aspartyl intramembranal protease composed of presenilin, Nicastrin, Aph1 and Pen2 with 19 transmembrane domains. γ-Secretase cleaves the amyloid precursor proteins (APP) to release Aβ peptides that likely play a causative role in the pathogenesis of Alzheimer disease (AD). In addit...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3796170/ https://ncbi.nlm.nih.gov/pubmed/23614767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400377p |
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