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Modulation of γ-secretase specificity using small molecule allosteric inhibitors
γ-Secretase cleaves multiple substrates within the transmembrane domain that include the amyloid precursor protein as well as the Notch family of receptors. These substrates are associated with Alzheimer disease and cancer. Despite extensive investigation of this protease, little is known regarding...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2787169/ https://ncbi.nlm.nih.gov/pubmed/19906985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910757106 |
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