Modulation of γ-secretase specificity using small molecule allosteric inhibitors

γ-Secretase cleaves multiple substrates within the transmembrane domain that include the amyloid precursor protein as well as the Notch family of receptors. These substrates are associated with Alzheimer disease and cancer. Despite extensive investigation of this protease, little is known regarding...

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Bibliographic Details
Main Authors: Shelton, Christopher C., Zhu, Lei, Chau, Deming, Yang, Li, Wang, Rong, Djaballah, Hakim, Zheng, Hui, Li, Yue-Ming
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787169/
https://ncbi.nlm.nih.gov/pubmed/19906985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910757106
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