A Miniaturized 1536-Well Format γ-Secretase Assay

γ-Secretase is an aspartyl protease that cleaves multiple substrates including the amyloid precursor protein (APP) and the Notch proteins. Abnormal proteolysis of APP is involved in the pathogenesis of Alzheimer’s disease (AD) and overactive Notch signaling plays an oncogenic role in a variety of ca...

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Detalhes bibliográficos
Main Authors: Shelton, Christopher C., Tian, Yuan, Shum, David, Radu, Constantin, Djaballah, Hakim, Li, Yue-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. publishers 2009
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096545/
https://ncbi.nlm.nih.gov/pubmed/19715456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2009.0202
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