A Miniaturized 1536-Well Format γ-Secretase Assay

γ-Secretase is an aspartyl protease that cleaves multiple substrates including the amyloid precursor protein (APP) and the Notch proteins. Abnormal proteolysis of APP is involved in the pathogenesis of Alzheimer’s disease (AD) and overactive Notch signaling plays an oncogenic role in a variety of ca...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Shelton, Christopher C., Tian, Yuan, Shum, David, Radu, Constantin, Djaballah, Hakim, Li, Yue-Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. publishers 2009
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096545/
https://ncbi.nlm.nih.gov/pubmed/19715456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2009.0202
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