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A Miniaturized 1536-Well Format γ-Secretase Assay
γ-Secretase is an aspartyl protease that cleaves multiple substrates including the amyloid precursor protein (APP) and the Notch proteins. Abnormal proteolysis of APP is involved in the pathogenesis of Alzheimer’s disease (AD) and overactive Notch signaling plays an oncogenic role in a variety of ca...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Mary Ann Liebert, Inc. publishers
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3096545/ https://ncbi.nlm.nih.gov/pubmed/19715456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2009.0202 |
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