Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors

von Hart, Amy C., Schroeder, Gretchen M., Wan, Honghe, Grebinski, James, Inghrim, Jennifer, Kempson, James, Guo, Junqing, Pitts, William J., Tokarski, John S., Sack, John S., Khan, Javed A., Lippy, Jonathan, Lorenzi, Matthew V., You, Dan, McDevitt, Theresa, Vuppugalla, Ragini, Zhang, Yueping, Lombardo, Louis J., Trainor, George L., Purandare, Ashok V.
Veröffentlicht in ACS Med Chem Lett (2015)

Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis

von Spergel, Steven H., Mertzman, Michael E., Kempson, James, Guo, Junqing, Stachura, Sylwia, Haque, Lauren, Lippy, Jonathan S., Zhang, Rosemary F., Galella, Michael, Pitt, Sidney, Shen, Guoxiang, Fura, Aberra, Gillooly, Kathleen, McIntyre, Kim W., Tang, Vicky, Tokarski, John, Sack, John S., Khan, Javed, Carter, Percy H., Barrish, Joel C., Nadler, Steven G., Salter-Cid, Luisa M., Schieven, Gary L., Wrobleski, Stephen T., Pitts, William J.
Veröffentlicht in ACS Med Chem Lett (2019)

Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK

von Srivastava, Anurag S., Ko, Soo, Watterson, Scott H., Pattoli, Mark A., Skala, Stacey, Cheng, Lihong, Obermeier, Mary T., Vickery, Rodney, Discenza, Lorell N., D’Arienzo, Celia J., Gillooly, Kathleen M., Taylor, Tracy L., Pulicicchio, Claudine, McIntyre, Kim W., Yip, Shiuhang, Li, Peng, Sun, Dawn, Wu, Dauh-Rurng, Dai, Jun, Wang, Chunlei, Zhang, Yingru, Wang, Bei, Pawluczyk, Joseph, Kempson, James, Zhao, Rulin, Hou, Xiaoping, Rampulla, Richard, Mathur, Arvind, Galella, Michael A., Salter-Cid, Luisa, Barrish, Joel C., Carter, Percy H., Fura, Aberra, Burke, James R., Tino, Joseph A.
Veröffentlicht in ACS Med Chem Lett (2020)

Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors

von Cherney, Emily C., Zhang, Liping, Guo, Weiwei, Huang, Audris, Williams, David, Seitz, Steven, Shan, Weifang, Zhu, Xiao, Gullo-Brown, Johnni, Maley, Derrick, Lin, Tai-an, Hunt, John T., Huang, Christine, Yang, Zheng, D’Arienzo, Celia J., Discenza, Lorell N., Ranasinghe, Asoka, Grubb, Mary F., Traeger, Sarah C., Li, Xin, Johnston, Kathy A., Kopcho, Lisa, Fereshteh, Mark, Foster, Kimberly A., Stefanski, Kevin, Delpy, Diane, Dhar, Gopal, Anandam, Aravind, Mahankali, Sandeep, Padmanabhan, Shweta, Rajanna, Prabhakar, Murali, Venkata, Mariappan, T. Thanga, Pattasseri, Shabeerali, Nimje, Roshan Y., Hong, Zhenqiu, Kempson, James, Rampulla, Richard, Mathur, Arvind, Gupta, Anuradha, Borzilleri, Robert, Vite, Gregory, Balog, Aaron
Veröffentlicht in ACS Med Chem Lett (2021)

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder

von Marcin, Lawrence R., Warrier, Jayakumar, Thangathirupathy, Srinivasan, Shi, Jianliang, Karageorge, George N., Pearce, Bradley C., Ng, Alicia, Park, Hyunsoo, Kempson, James, Li, Jianqing, Zhang, Huiping, Mathur, Arvind, Reddy, Aliphedi B., Nagaraju, G., Tonukunuru, Gopikishan, Gupta, Grandhi V. R. K. M., Kamble, Manjunatha, Mannoori, Raju, Cheruku, Srinivas, Jogi, Srinivas, Gulia, Jyoti, Bastia, Tanmaya, Sanmathi, Charulatha, Aher, Jayant, Kallem, Rajareddy, Srikumar, Bettadapura N., Vijaya, Kumar Kuchibhotla, Naidu, Pattipati S., Paschapur, Mahesh, Kalidindi, Narasimharaju, Vikramadithyan, Reeba, Ramarao, Manjunath, Denton, Rex, Molski, Thaddeus, Shields, Eric, Subramanian, Murali, Zhuo, Xiaoliang, Nophsker, Michelle, Simmermacher, Jean, Sinz, Michael, Albright, Charlie, Bristow, Linda J., Islam, Imadul, Bronson, Joanne J., Olson, Richard E., King, Dalton, Thompson, Lorin A., Macor, John E.
Veröffentlicht in ACS Med Chem Lett (2018)