Human Artificial Chromosomes for Gene Delivery and the Development of Animal Models

Autor Kazuki, Yasuhiro, Oshimura, Mitsuo
Vydáno 2011

Application of a Bacterial Artificial Chromosome Modification System for a Human Artificial Chromosome Vector

Autor Yamaguchi, Shigeyuki, Niwa, Ryosuke, Kazuki, Yasuhiro, Ohbayashi, Tetsuya
Vydáno 2011

A Novel System for Simultaneous or Sequential Integration of Multiple Gene-Loading Vectors into a Defined Site of a Human Artificial Chromosome

Autor Suzuki, Teruhiko, Kazuki, Yasuhiro, Oshimura, Mitsuo, Hara, Takahiko
Vydáno 2014

Highly Efficient Transfer of Chromosomes to a Broad Range of Target Cells Using Chinese Hamster Ovary Cells Expressing Murine Leukemia Virus-Derived Envelope Proteins

Autor Suzuki, Teruhiko, Kazuki, Yasuhiro, Oshimura, Mitsuo, Hara, Takahiko
Vydáno v PLoS One (2016)

A Human Artificial Chromosome Recapitulates the Metabolism of Native Telomeres in Mammalian Cells

Autor Wakai, Michihito, Abe, Satoshi, Kazuki, Yasuhiro, Oshimura, Mitsuo, Ishikawa, Fuyuki
Vydáno 2014

A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges

Autor Oshimura, Mitsuo, Uno, Narumi, Kazuki, Yasuhiro, Katoh, Motonobu, Inoue, Toshiaki
Vydáno v Chromosome Res (2015)

Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells

Autor Iwado, Satoru, Abe, Satoshi, Oshimura, Mitsuo, Kazuki, Yasuhiro, Nakajima, Yoshihiro
Vydáno v Int J Mol Sci (2021)

A Method for Producing Transgenic Cells Using a Multi-Integrase System on a Human Artificial Chromosome Vector

Autor Yamaguchi, Shigeyuki, Kazuki, Yasuhiro, Nakayama, Yuji, Nanba, Eiji, Oshimura, Mitsuo, Ohbayashi, Tetsuya
Vydáno 2011

CRISPR/Cas9-induced transgene insertion and telomere-associated truncation of a single human chromosome for chromosome engineering in CHO and A9 cells

Autor Uno, Narumi, Hiramatsu, Kei, Uno, Katsuhiro, Komoto, Shinya, Kazuki, Yasuhiro, Oshimura, Mitsuo
Vydáno v Sci Rep (2017)

Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome

Autor Ohta, Yumi, Kazuki, Kanako, Abe, Satoshi, Oshimura, Mitsuo, Kobayashi, Kaoru, Kazuki, Yasuhiro
Vydáno v BMC Biotechnol (2020)

Establishment and Characterization of a Transgenic Mouse Model for In Vivo Imaging of Bmp4 Expression in the Pancreas

Autor Yasunaga, Mayu, Oumi, Nao, Osaki, Mitsuhiko, Kazuki, Yasuhiro, Nakanishi, Tomoko, Oshimura, Mitsuo, Sato, Kenzo
Vydáno 2011

Evaluation of an Hprt-Luciferase Reporter Gene on a Mammalian Artificial Chromosome in Response to Cytotoxicity

Autor Endo, Takeshi, Noda, Natsumi, Kuromi, Yasushi, Kokura, Kenji, Kazuki, Yasuhiro, Oshimura, Mitsuo, Ohbayashi, Tetsuya
Vydáno v Yonago Acta Med (2016)

A kidney injury molecule‐1 (Kim‐1) gene reporter in a mouse artificial chromosome: the responsiveness to cisplatin toxicity in immortalized mouse kidney S3 cells

Autor Kokura, Kenji, Kuromi, Yasushi, Endo, Takeshi, Anzai, Naohiko, Kazuki, Yasuhiro, Oshimura, Mitsuo, Ohbayashi, Tetsuya
Vydáno v J Gene Med (2016)

Establishment of a novel hepatocyte model that expresses four cytochrome P450 genes stably via mammalian-derived artificial chromosome for pharmacokinetics and toxicity studies

Autor Satoh, Daisuke, Iwado, Satoru, Abe, Satoshi, Kazuki, Kanako, Wakuri, Shinobu, Oshimura, Mitsuo, Kazuki, Yasuhiro
Vydáno v PLoS One (2017)

Development of a multiple-gene-loading method by combining multi-integration system-equipped mouse artificial chromosome vector and CRISPR-Cas9

Autor Honma, Kazuhisa, Abe, Satoshi, Endo, Takeshi, Uno, Narumi, Oshimura, Mitsuo, Ohbayashi, Tetsuya, Kazuki, Yasuhiro
Vydáno v PLoS One (2018)

An efficient protein production system via gene amplification on a human artificial chromosome and the chromosome transfer to CHO cells

Autor Ohira, Takahito, Miyauchi, Koichi, Uno, Narumi, Shimizu, Noriaki, Kazuki, Yasuhiro, Oshimura, Mitsuo, Kugoh, Hiroyuki
Vydáno v Sci Rep (2019)

Exploitation of the interaction of measles virus fusogenic envelope proteins with the surface receptor CD46 on human cells for microcell-mediated chromosome transfer

Autor Katoh, Motonobu, Kazuki, Yasuhiro, Kazuki, Kanako, Kajitani, Naoyo, Takiguchi, Masato, Nakayama, Yuji, Nakamura, Takafumi, Oshimura, Mitsuo
Vydáno 2010

A bi-HAC vector system towards gene and cell therapy

Autor Iida, Yuichi, Kazuki, Yasuhiro, Hayashi, Masahiro, Ueda, Yasuji, Hasegawa, Mamoru, Kouprina, Natalay, Larionov, Vladimir, Oshimura, Mitsuo
Vydáno 2014

Complete restoration of multiple dystrophin isoforms in genetically corrected Duchenne muscular dystrophy patient–derived cardiomyocytes

Autor Zatti, Susi, Martewicz, Sebastian, Serena, Elena, Uno, Narumi, Giobbe, Giovanni, Kazuki, Yasuhiro, Oshimura, Mitsuo, Elvassore, Nicola
Vydáno v Mol Ther Methods Clin Dev (2014)

Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy

Autor Uno, Narumi, Uno, Katsuhiro, Komoto, Shinya, Suzuki, Teruhiko, Hiratsuka, Masaharu, Osaki, Mitsuhiko, Kazuki, Yasuhiro, Oshimura, Mitsuo
Vydáno v Mol Ther Nucleic Acids (2015)