Human Artificial Chromosomes for Gene Delivery and the Development of Animal Models

מאת Kazuki, Yasuhiro, Oshimura, Mitsuo
יצא לאור 2011

Application of a Bacterial Artificial Chromosome Modification System for a Human Artificial Chromosome Vector

מאת Yamaguchi, Shigeyuki, Niwa, Ryosuke, Kazuki, Yasuhiro, Ohbayashi, Tetsuya
יצא לאור 2011

A Novel System for Simultaneous or Sequential Integration of Multiple Gene-Loading Vectors into a Defined Site of a Human Artificial Chromosome

מאת Suzuki, Teruhiko, Kazuki, Yasuhiro, Oshimura, Mitsuo, Hara, Takahiko
יצא לאור 2014

Highly Efficient Transfer of Chromosomes to a Broad Range of Target Cells Using Chinese Hamster Ovary Cells Expressing Murine Leukemia Virus-Derived Envelope Proteins

מאת Suzuki, Teruhiko, Kazuki, Yasuhiro, Oshimura, Mitsuo, Hara, Takahiko
הוצא לאור ב PLoS One (2016)

A Human Artificial Chromosome Recapitulates the Metabolism of Native Telomeres in Mammalian Cells

מאת Wakai, Michihito, Abe, Satoshi, Kazuki, Yasuhiro, Oshimura, Mitsuo, Ishikawa, Fuyuki
יצא לאור 2014

A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges

מאת Oshimura, Mitsuo, Uno, Narumi, Kazuki, Yasuhiro, Katoh, Motonobu, Inoue, Toshiaki
הוצא לאור ב Chromosome Res (2015)

Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells

מאת Iwado, Satoru, Abe, Satoshi, Oshimura, Mitsuo, Kazuki, Yasuhiro, Nakajima, Yoshihiro
הוצא לאור ב Int J Mol Sci (2021)

A Method for Producing Transgenic Cells Using a Multi-Integrase System on a Human Artificial Chromosome Vector

מאת Yamaguchi, Shigeyuki, Kazuki, Yasuhiro, Nakayama, Yuji, Nanba, Eiji, Oshimura, Mitsuo, Ohbayashi, Tetsuya
יצא לאור 2011

CRISPR/Cas9-induced transgene insertion and telomere-associated truncation of a single human chromosome for chromosome engineering in CHO and A9 cells

מאת Uno, Narumi, Hiramatsu, Kei, Uno, Katsuhiro, Komoto, Shinya, Kazuki, Yasuhiro, Oshimura, Mitsuo
הוצא לאור ב Sci Rep (2017)

Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome

מאת Ohta, Yumi, Kazuki, Kanako, Abe, Satoshi, Oshimura, Mitsuo, Kobayashi, Kaoru, Kazuki, Yasuhiro
הוצא לאור ב BMC Biotechnol (2020)

Establishment and Characterization of a Transgenic Mouse Model for In Vivo Imaging of Bmp4 Expression in the Pancreas

מאת Yasunaga, Mayu, Oumi, Nao, Osaki, Mitsuhiko, Kazuki, Yasuhiro, Nakanishi, Tomoko, Oshimura, Mitsuo, Sato, Kenzo
יצא לאור 2011

Evaluation of an Hprt-Luciferase Reporter Gene on a Mammalian Artificial Chromosome in Response to Cytotoxicity

מאת Endo, Takeshi, Noda, Natsumi, Kuromi, Yasushi, Kokura, Kenji, Kazuki, Yasuhiro, Oshimura, Mitsuo, Ohbayashi, Tetsuya
הוצא לאור ב Yonago Acta Med (2016)

A kidney injury molecule‐1 (Kim‐1) gene reporter in a mouse artificial chromosome: the responsiveness to cisplatin toxicity in immortalized mouse kidney S3 cells

מאת Kokura, Kenji, Kuromi, Yasushi, Endo, Takeshi, Anzai, Naohiko, Kazuki, Yasuhiro, Oshimura, Mitsuo, Ohbayashi, Tetsuya
הוצא לאור ב J Gene Med (2016)

Establishment of a novel hepatocyte model that expresses four cytochrome P450 genes stably via mammalian-derived artificial chromosome for pharmacokinetics and toxicity studies

מאת Satoh, Daisuke, Iwado, Satoru, Abe, Satoshi, Kazuki, Kanako, Wakuri, Shinobu, Oshimura, Mitsuo, Kazuki, Yasuhiro
הוצא לאור ב PLoS One (2017)

Development of a multiple-gene-loading method by combining multi-integration system-equipped mouse artificial chromosome vector and CRISPR-Cas9

מאת Honma, Kazuhisa, Abe, Satoshi, Endo, Takeshi, Uno, Narumi, Oshimura, Mitsuo, Ohbayashi, Tetsuya, Kazuki, Yasuhiro
הוצא לאור ב PLoS One (2018)

An efficient protein production system via gene amplification on a human artificial chromosome and the chromosome transfer to CHO cells

מאת Ohira, Takahito, Miyauchi, Koichi, Uno, Narumi, Shimizu, Noriaki, Kazuki, Yasuhiro, Oshimura, Mitsuo, Kugoh, Hiroyuki
הוצא לאור ב Sci Rep (2019)

Exploitation of the interaction of measles virus fusogenic envelope proteins with the surface receptor CD46 on human cells for microcell-mediated chromosome transfer

מאת Katoh, Motonobu, Kazuki, Yasuhiro, Kazuki, Kanako, Kajitani, Naoyo, Takiguchi, Masato, Nakayama, Yuji, Nakamura, Takafumi, Oshimura, Mitsuo
יצא לאור 2010

A bi-HAC vector system towards gene and cell therapy

מאת Iida, Yuichi, Kazuki, Yasuhiro, Hayashi, Masahiro, Ueda, Yasuji, Hasegawa, Mamoru, Kouprina, Natalay, Larionov, Vladimir, Oshimura, Mitsuo
יצא לאור 2014

Complete restoration of multiple dystrophin isoforms in genetically corrected Duchenne muscular dystrophy patient–derived cardiomyocytes

מאת Zatti, Susi, Martewicz, Sebastian, Serena, Elena, Uno, Narumi, Giobbe, Giovanni, Kazuki, Yasuhiro, Oshimura, Mitsuo, Elvassore, Nicola
הוצא לאור ב Mol Ther Methods Clin Dev (2014)

Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy

מאת Uno, Narumi, Uno, Katsuhiro, Komoto, Shinya, Suzuki, Teruhiko, Hiratsuka, Masaharu, Osaki, Mitsuhiko, Kazuki, Yasuhiro, Oshimura, Mitsuo
הוצא לאור ב Mol Ther Nucleic Acids (2015)