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Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome

BACKGROUND: Oral administration is the most common way to deliver drugs to the systemic circulation or target organs. Orally administered drugs are absorbed in the intestine and metabolized in the intestine and liver. In the early stages of drug development, it is important to predict first-pass met...

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Detalhes bibliográficos
Publicado no:BMC Biotechnol
Main Authors: Ohta, Yumi, Kazuki, Kanako, Abe, Satoshi, Oshimura, Mitsuo, Kobayashi, Kaoru, Kazuki, Yasuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7441628/
https://ncbi.nlm.nih.gov/pubmed/32819341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-020-00637-8
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