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Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model
Thalidomide is a teratogen in humans but not in rodents. It causes multiple birth defects including malformations of limbs, ears, and other organs. However, the species-specific mechanism of thalidomide teratogenicity is not completely understood. Reproduction of the human teratogenicity of thalidom...
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| Publié dans: | Sci Rep |
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| Auteurs principaux: | , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4763305/ https://ncbi.nlm.nih.gov/pubmed/26903378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21419 |
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