Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells

We sought to develop a cell-based cytotoxicity assay using human hepatocytes, which reflect the effects of drug-metabolizing enzymes on cytotoxicity. In this study, we generated luminescent human hepatoblastoma HepG2 cells using the mouse artificial chromosome vector, in which click beetle luciferas...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Iwado, Satoru, Abe, Satoshi, Oshimura, Mitsuo, Kazuki, Yasuhiro, Nakajima, Yoshihiro
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7999318/
https://ncbi.nlm.nih.gov/pubmed/33799598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22062843
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