Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome

BACKGROUND: Oral administration is the most common way to deliver drugs to the systemic circulation or target organs. Orally administered drugs are absorbed in the intestine and metabolized in the intestine and liver. In the early stages of drug development, it is important to predict first-pass met...

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Bibliografske podrobnosti
izdano v:BMC Biotechnol
Main Authors: Ohta, Yumi, Kazuki, Kanako, Abe, Satoshi, Oshimura, Mitsuo, Kobayashi, Kaoru, Kazuki, Yasuhiro
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7441628/
https://ncbi.nlm.nih.gov/pubmed/32819341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-020-00637-8
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