Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy

The development of a safeguard system to remove tumorigenic cells would allow safer clinical applications of stem cells for the treatment of patients with an intractable disease including genetic disorders. Such safeguard systems should not disrupt the host genome and should have long-term stability...

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Bibliografske podrobnosti
izdano v:Mol Ther Nucleic Acids
Main Authors: Uno, Narumi, Uno, Katsuhiro, Komoto, Shinya, Suzuki, Teruhiko, Hiratsuka, Masaharu, Osaki, Mitsuhiko, Kazuki, Yasuhiro, Oshimura, Mitsuo
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014537/
https://ncbi.nlm.nih.gov/pubmed/26670279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.45
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