CRISPR/Cas9-induced transgene insertion and telomere-associated truncation of a single human chromosome for chromosome engineering in CHO and A9 cells

Chromosome engineering techniques including gene insertion, telomere-associated truncation and microcell-mediated chromosome transfer (MMCT) are powerful tools for generation of humanised model animal, containing megabase-sized genomic fragments. However, these techniques require two cell lines: hom...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Uno, Narumi, Hiramatsu, Kei, Uno, Katsuhiro, Komoto, Shinya, Kazuki, Yasuhiro, Oshimura, Mitsuo
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630592/
https://ncbi.nlm.nih.gov/pubmed/28986519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10418-7
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