Development of a multiple-gene-loading method by combining multi-integration system-equipped mouse artificial chromosome vector and CRISPR-Cas9

Mouse artificial chromosome (MAC) vectors have several advantages as gene delivery vectors, such as stable and independent maintenance in host cells without integration, transferability from donor cells to recipient cells via microcell-mediated chromosome transfer (MMCT), and the potential for loadi...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Honma, Kazuhisa, Abe, Satoshi, Endo, Takeshi, Uno, Narumi, Oshimura, Mitsuo, Ohbayashi, Tetsuya, Kazuki, Yasuhiro
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837097/
https://ncbi.nlm.nih.gov/pubmed/29505588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193642
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