Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy

The development of a safeguard system to remove tumorigenic cells would allow safer clinical applications of stem cells for the treatment of patients with an intractable disease including genetic disorders. Such safeguard systems should not disrupt the host genome and should have long-term stability...

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Veröffentlicht in:Mol Ther Nucleic Acids
Hauptverfasser: Uno, Narumi, Uno, Katsuhiro, Komoto, Shinya, Suzuki, Teruhiko, Hiratsuka, Masaharu, Osaki, Mitsuhiko, Kazuki, Yasuhiro, Oshimura, Mitsuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014537/
https://ncbi.nlm.nih.gov/pubmed/26670279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.45
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