Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor–induced STAT1 activation

由 Bhattacharyya, Sandip, Zhao, Yuxing, Kay, Thomas W. H., Muglia, Louis J.
出版 2011

Insulin teaches a new lesson in tolerance

由 Kay, Thomas W H, Krishnamurthy, Bala, Brodnicki, Thomas C, Mannering, Stuart I
出版 2009

Severe Pancreatitis with Exocrine Destruction and Increased Islet Neogenesis in Mice with Suppressor of Cytokine Signaling-1 Deficiency

由 Chen, Ye, Chong, Mark M.W., Darwiche, Rima, Thomas, Helen E., Kay, Thomas W.H.
出版 2004

Rotavirus Infection Accelerates Type 1 Diabetes in Mice with Established Insulitis

由 Graham, Kate L., Sanders, Natalie, Tan, Yan, Allison, Janette, Kay, Thomas W. H., Coulson, Barbara S.
出版 2008

Lack of Expression of Gp-130 Makes Pancreatic Beta Cell Lines Unresponsive to the IL-6 Family of Cytokines

由 Naselli, Gaetano, Deaizpurua, Henry J., Thomas, Helen E., Johnston, Anne M., Kay, Thomas W. H.
出版 2000

IL-17F induces inflammation, dysfunction and cell death in mouse islets

由 Catterall, Tara, Fynch, Stacey, Kay, Thomas W. H., Thomas, Helen E., Sutherland, Andrew P. R.
發表在 Sci Rep (2020)

Prevention of “Humanized” Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach

由 Niens, Marijke, Grier, Alexandra E., Marron, Michele, Kay, Thomas W.H., Greiner, Dale L., Serreze, David V.
出版 2011

IFNγ-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4(+) T Cell Migration

由 Scott, Nicholas A., Zhao, Yuxing, Krishnamurthy, Balasubramanian, Mannering, Stuart I., Kay, Thomas W. H., Thomas, Helen E.
發表在 Front Immunol (2018)

Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling

由 Pane, Jessica A., Fleming, Fiona E., Graham, Kate L., Thomas, Helen E., Kay, Thomas W. H., Coulson, Barbara S.
發表在 Sci Rep (2016)

NF-κB is weakly activated in the NOD mouse model of type 1 diabetes

由 Irvin, Allison E., Jhala, Gaurang, Zhao, Yuxing, Blackwell, Timothy S., Krishnamurthy, Balasubramanian, Thomas, Helen E., Kay, Thomas W. H.
發表在 Sci Rep (2018)

Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice

由 Jhala, Gaurang, Selck, Claudia, Chee, Jonathan, Kwong, Chun-Ting J., Pappas, Evan G., Thomas, Helen E., Kay, Thomas W.H., Krishnamurthy, Balasubramanian
發表在 Front Immunol (2021)

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

由 Coppieters, Ken T., Dotta, Francesco, Amirian, Natalie, Campbell, Peter D., Kay, Thomas W.H., Atkinson, Mark A., Roep, Bart O., von Herrath, Matthias G.
出版 2012

Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes

由 Jhala, Gaurang, Chee, Jonathan, Trivedi, Prerak M., Selck, Claudia, Gurzov, Esteban N., Graham, Kate L., Thomas, Helen E., Kay, Thomas W.H., Krishnamurthy, Balasubramanian
發表在 JCI Insight (2016)

IL-21 regulates SOCS1 expression in autoreactive CD8(+) T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice

由 Sutherland, Andrew P. R., Graham, Kate L., Papadimitriou, Michelle, Jhala, Gaurang, Trivedi, Prerak, Catterall, Tara, Fynch, Stacey, Kay, Thomas W. H., Thomas, Helen E.
發表在 Sci Rep (2019)

Pathogenic Mechanisms in Type 1 Diabetes: The Islet is Both Target and Driver of Disease

由 Graham, Kate L., Sutherland, Robyn M., Mannering, Stuart I., Zhao, Yuxing, Chee, Jonathan, Krishnamurthy, Balasubramanian, Thomas, Helen E., Lew, Andrew M., Kay, Thomas W.H.
出版 2012

Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice

由 Trivedi, Prerak M., Fynch, Stacey, Kennedy, Lucy M., Chee, Jonathan, Krishnamurthy, Balasubramanian, O’Reilly, Lorraine A., Strasser, Andreas, Kay, Thomas W. H., Thomas, Helen E.
發表在 Cell Death Discov (2019)

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells

由 Krishnamurthy, Balasubramanian, Chee, Jonathan, Jhala, Gaurang, Fynch, Stacey, Graham, Kate L., Santamaria, Pere, Morahan, Grant, Allison, Janette, Izon, David, Thomas, Helen E., Kay, Thomas W.H.
出版 2012

Perturbed thymopoiesis in vitro in the absence of Suppressor of Cytokine Signalling 1 and 3

由 Croom, Hayley A., Izon, David J., Chong, Mark M., Curtis, David J., Roberts, Andrew W., Kay, Thomas W.H., Hilton, Douglas J., Alexander, Warren S., Starr, Robyn
發表在 Mol Immunol (2008)

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax

由 McKenzie, Mark D., Jamieson, Emma, Jansen, Elisa S., Scott, Clare L., Huang, David C.S., Bouillet, Philippe, Allison, Janette, Kay, Thomas W.H., Strasser, Andreas, Thomas, Helen E.
出版 2010

Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells: Implications for the Timing of Tolerizi...

由 Bertin-Maghit, Sebastien, Pang, Dimeng, O'Sullivan, Brendan, Best, Shannon, Duggan, Emily, Paul, Sanjoy, Thomas, Helen, Kay, Thomas W.H., Harrison, Leonard C., Steptoe, Raymond, Thomas, Ranjeny
出版 2011