Prevention of “Humanized” Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach

OBJECTIVE: Type 1 diabetes can be inhibited in standard NOD mice by autoantigen-specific immunotherapy targeting pathogenic CD8+ T-cells. NOD.β2m(null).HHD mice expressing human HLA-A2.1 but lacking murine major histocompatibility complex class I molecules develop diabetes characterized by CD8 T-cel...

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Detalhes bibliográficos
Main Authors: Niens, Marijke, Grier, Alexandra E., Marron, Michele, Kay, Thomas W.H., Greiner, Dale L., Serreze, David V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Immunology and Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064096/
https://ncbi.nlm.nih.gov/pubmed/21346176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1523
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