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Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development

Improved mouse models for type 1 diabetes (T1D) therapy development are needed. T1D susceptibility is restored to normally resistant NOD.β2m(−/−) mice transgenically expressing human disease–associated HLA-A*02:01 or HLA-B*39:06 class I molecules in place of their murine counterparts. T1D is depende...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Diabetes
मुख्य लेखकों: Racine, Jeremy J., Stewart, Isabel, Ratiu, Jeremy, Christianson, Greg, Lowell, Emily, Helm, Kelsay, Allocco, Jennifer, Maser, Richard S., Chen, Yi-Guang, Lutz, Cathleen M., Roopenian, Derry, Schloss, Jennifer, DiLorenzo, Teresa P., Serreze, David V.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Diabetes Association 2018
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909999/
https://ncbi.nlm.nih.gov/pubmed/29472249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1467
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