Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development

Improved mouse models for type 1 diabetes (T1D) therapy development are needed. T1D susceptibility is restored to normally resistant NOD.β2m(−/−) mice transgenically expressing human disease–associated HLA-A*02:01 or HLA-B*39:06 class I molecules in place of their murine counterparts. T1D is depende...

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Bibliographic Details
Published in:Diabetes
Main Authors: Racine, Jeremy J., Stewart, Isabel, Ratiu, Jeremy, Christianson, Greg, Lowell, Emily, Helm, Kelsay, Allocco, Jennifer, Maser, Richard S., Chen, Yi-Guang, Lutz, Cathleen M., Roopenian, Derry, Schloss, Jennifer, DiLorenzo, Teresa P., Serreze, David V.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2018
Subjects:
Immunology and Transplantation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909999/
https://ncbi.nlm.nih.gov/pubmed/29472249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1467
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