B-Lymphocytes Expressing an Ig Specificity Recognizing the Pancreatic β-Cell Autoantigen Peripherin Are Potent Contributors to Type 1 Diabetes Development in NOD Mice

Although the autoimmune destruction of pancreatic β-cells underlying type 1 diabetes (T1D) development is ultimately mediated by T cells in NOD mice and also likely in humans, B cells play an additional key pathogenic role. It appears that the expression of plasma membrane–bound Ig molecules that ef...

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Vydáno v:Diabetes
Hlavní autoři: Leeth, Caroline M., Racine, Jeremy, Chapman, Harold D., Arpa, Berta, Carrillo, Jorge, Carrascal, Jorge, Wang, Qiming, Ratiu, Jeremy, Egia-Mendikute, Leire, Rosell-Mases, Estela, Stratmann, Thomas, Verdaguer, Joan, Serreze, David V.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2016
Témata:
Immunology and Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915583/
https://ncbi.nlm.nih.gov/pubmed/26961115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1606
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