A hypermorphic Nfkbid allele contributes to impaired thymic deletion of autoreactive diabetogenic CD8(+) T-cells in NOD mice(,)

In both NOD mice and humans, the development of type 1 diabetes (T1D) is dependent in part on autoreactive CD8(+) T-cells recognizing pancreatic ß-cell peptides presented by often quite common MHC class I variants. Studies in NOD mice previously revealed the common H2-K(d) and/or H2-D(b) class I mol...

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Publicado no:J Immunol
Main Authors: Presa, Maximiliano, Racine, Jeremy J., Dwyer, Jennifer R., Lamont, Deanna J., Ratiu, Jeremy J., Sarsani, Vishal Kumar, Chen, Yi-Guang, Geurts, Aron, Schmitz, Ingo, Stearns, Timothy, Allocco, Jennifer, Chapman, Harold D., Serreze, David V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143397/
https://ncbi.nlm.nih.gov/pubmed/30127089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800465
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