Zinc finger nucleases: new strategies to target the rat genome

Por Geurts, Aron M., Moreno, Carol
Publicado em 2010

A RATional choice for translational research?

Por Aitman, Tim, Dhillon, Paraminder, Geurts, Aron M.
Publicado no Dis Model Mech (2016)

Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy

Por Hackett, Christopher S, Geurts, Aron M, Hackett, Perry B
Publicado em 2007

The emerging role for rat models in gene discovery

Por Dwinell, Melinda R., Lazar, Jozef, Geurts, Aron M.
Publicado em 2011

Myosin Id is required for planar cell polarity in ciliated tracheal and ependymal epithelial cells

Por Hegan, Peter S., Ostertag, Eric, Geurts, Aron M., Mooseker, Mark S.
Publicado no Cytoskeleton (Hoboken) (2015)

Two-photon Imaging of Intracellular Ca(2+) Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta

Por Endres, Bradley T., Staruschenko, Alexander, Schulte, Marie, Geurts, Aron M., Palygin, Oleg
Publicado no J Vis Exp (2015)

Rab38 Modulates Proteinuria in Model of Hypertension-Associated Renal Disease

Por Rangel-Filho, Artur, Lazar, Jozef, Moreno, Carol, Geurts, Aron, Jacob, Howard J.
Publicado em 2013

Gene Targeting in the Rat: Advances and Opportunities

Por Jacob, Howard J., Lazar, Jozef, Dwinell, Melinda R., Moreno, Carol, Geurts, Aron M.
Publicado em 2010

CD247 Modulates Blood Pressure by Altering T Lymphocyte Infiltration in the Kidney

Por Rudemiller, Nathan, Lund, Hayley, Jacob, Howard J., Geurts, Aron M, Mattson, David L.
Publicado em 2013

Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage

Por Mattson, David L., Lund, Hayley, Guo, Chuanling, Rudemiller, Nathan, Geurts, Aron M., Jacob, Howard
Publicado em 2013

2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research

Por Flister, Michael J., Prokop, Jeremy W., Lazar, Jozef, Shimoyama, Mary, Dwinell, Melinda, Geurts, Aron
Publicado no J Cardiovasc Transl Res (2015)

Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury

Por Chen, Chun Cheng Andy, Geurts, Aron M., Jacob, Howard J., Fan, Fan, Roman, Richard J.
Publicado em 2013

Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice

Por Park, Anna Kyunglim, Liegel, Ryan P, Ronchetti, Adam, Ebert, Allison D, Geurts, Aron, Sidjanin, Duska J
Publicado no BMC Genet (2014)

Gene Targeting in NOD Mouse Embryos Using Zinc-Finger Nucleases

Por Chen, Yi-Guang, Forsberg, Matthew H., Khaja, Shamim, Ciecko, Ashley E., Hessner, Martin J., Geurts, Aron M.
Publicado em 2014

Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat

Por Fan, Fan, Geurts, Aron M., Murphy, Sydney R., Pabbidi, Mallikarjuna R., Jacob, Howard J., Roman, Richard J.
Publicado no Am J Physiol Regul Integr Comp Physiol (2014)

The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction

Por Priestley, Jessica R. C., Kautenburg, Katie E., Casati, Marc C., Endres, Bradley T., Geurts, Aron M., Lombard, Julian H.
Publicado no Am J Physiol Heart Circ Physiol (2015)

Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats

Por Kaplan, Kara, Echert, Ashley E., Massat, Ben, Puissant, Madeleine M., Palygin, Oleg, Geurts, Aron M., Hodges, Matthew R.
Publicado no J Appl Physiol (1985) (2016)

Zinc-Finger Nuclease Knockout of Dual-Specificity Protein Phosphatase-5 Enhances the Myogenic Response and Autoregulation of Cerebral Blood Flow in FHH.1(BN) Rats

Por Fan, Fan, Geurts, Aron M., Pabbidi, Mallikarjuna R., Smith, Stanley V., Harder, David R., Jacob, Howard, Roman, Richard J.
Publicado no PLoS One (2014)

Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension

Por Feng, Di, Yang, Chun, Geurts, Aron, Kurth, Terry, Liang, Mingyu, Lazar, Jozef, Mattson, Dave, O’Connor, Paul, Cowley, Allen W.
Publicado em 2012

Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury

Por Wang, Feng, Zhang, Guangyuan, Lu, Zeyuan, Geurts, Aron M, Usa, Kristie, Jacob, Howard J, Cowley, Allen W, Wang, Niansong, Liang, Mingyu
Publicado no Kidney Int (2015)