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Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury
The present study employed a zinc-finger nuclease strategy to create heterozygous knockout (KO) rats for the transforming growth factor-β1 (Tgfb1) gene on the Dahl SS/Jr genetic background (TGF-β1(+/−) Dahl S). Intercrossing TGF-β1(+/−) rats did not produce any homozygous KO rats (66.4% +/−, 33.6% +...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3568879/ https://ncbi.nlm.nih.gov/pubmed/23249995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00119.2012 |
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