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A hypermorphic Nfkbid allele contributes to impaired thymic deletion of autoreactive diabetogenic CD8(+) T-cells in NOD mice(,)
In both NOD mice and humans, the development of type 1 diabetes (T1D) is dependent in part on autoreactive CD8(+) T-cells recognizing pancreatic ß-cell peptides presented by often quite common MHC class I variants. Studies in NOD mice previously revealed the common H2-K(d) and/or H2-D(b) class I mol...
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| Pubblicato in: | J Immunol |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6143397/ https://ncbi.nlm.nih.gov/pubmed/30127089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800465 |
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