Idd9/11 Genetic Locus Regulates Diabetogenic Activity of CD4 T-Cells in Nonobese Diabetic (NOD) Mice

OBJECTIVE—Although the H2(g7) major histocompatibility complex (MHC) provides the primary pathogenic component, the development of T-cell–mediated autoimmune type 1 diabetes in NOD mice also requires contributions from other susceptibility (Idd) genes. Despite sharing the H2(g7) MHC, the closely NOD...

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Autori principali: Chen, Yi-Guang, Scheuplein, Felix, Osborne, Melissa A., Tsaih, Shirng-Wern, Chapman, Harold D., Serreze, David V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2008
Soggetti:
Immunology and Transplantation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584133/
https://ncbi.nlm.nih.gov/pubmed/18776136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0767
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