Subcongenic analyses reveal complex interactions between distal Chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in NOD mice.

Autoimmune Type 1 Diabetes (T1D) in humans and NOD mice results from interactions between multiple susceptibility genes (termed Idd) located within and outside the MHC. Despite sharing ~88% of their genome with NOD, including the H2(g7) MHC haplotype and other important Idd genes, the closely relate...

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Main Authors: Stolp, Jessica, Chen, Yi-Guang, Cox, Selwyn L., Henck, Vivien, Zhang, Wenyu, Tsaih, Shirng-Wern, Chapman, Harold, Stearns, Timothy, Serreze, David V., Silveira, Pablo A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401322/
https://ncbi.nlm.nih.gov/pubmed/22732593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200120
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